THE LXR-IDOL AXIS DEFINES A CLATHRIN-, CAVEOLAE-, AND DYNAMIN-INDEPENDENT ENDOCYTIC ROUTE FOR LDLR INTERNALIZATION AND LYSOSOMAL DEGRADATION

The LXR-IDOL axis defines a clathrin-, caveolae-, and dynamin-independent endocytic route for LDLR internalization and lysosomal degradation

Low density lipoprotein (LDL) cholesterol is taken up into cells via clathrin-mediated endocytosis of the LDL receptor (LDLR).Following dissociation of the LDLR-LDL complex, LDL is directed to lysosomes whereas the LDLR recycles to the plasma membrane.Activation of the sterol-sensing nuclear receptors liver X receptors (LXRs) enhances degradation o

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"Non-Eloquent" brain regions predict neuropsychological outcome in tumor patients undergoing awake craniotomy.

Supratotal resection of primary brain tumors is being advocated especially when involving "non-eloquent" tissue.However, there is extensive neuropsychological data implicating functions critical to higher cognition in areas considered "non-eloquent" by most surgeons.The goal of the study was to fg42 replica determine pre-surgical brain regions that

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WATER RESOURCES STATUS AND AVAILABILITY ASSESSMENT IN CURRENT AND FUTURE CLIMATE CHANGE SCENARIOS FOR BEAS RIVER BASIN OF NORTH WESTERN HIMALAYA

The water resources status and availability of any river basin is of primary importance for overall and sustainable development of any river basin.This study has been done in Beas river basin which is located in North Western Himalaya for assessing the status of water resources in present and future climate change scenarios.In this study hydrologic

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Phagocytosis Assay of Necroptotic Cells by Cardiac Myofibroblasts

In myocardial infarction (MI), a plenty of cardiomyocytes undergo necrosis and necroptosis due to the lack of oxygen and nutrients.The dead cardiomyocytes are promptly engulfed kaiser copy stands by phagocytes.When the dead cells are not engulfed, the noxious contents of the jumbo gourmet tava cells are released outside, and thus, induce inflammati

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Influence of the structural changes on cavitation resistance of Al18SiCuMg alloy produced by rheocasting process

The influence of stirring speeds of 1000 and 1500 r/min on the microstructure of Al18SiCuMg alloy was investigated.The smaller size of Si particles of rheocast sample led cocktail smoker obtained by higher cooling rate and higher stirring speed was achieved.According to the results of cavitation test, the cavitation rate of the 2005 honda accord in

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